CD34 Antikörper

Produktnummer ABIN155167

Dieser Maus Monoklonal Antikörper erkennt spezifisch CD34 in FACS und IHC (fro). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CD34 Antikörper (ABIN155167)

Target: CD34

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD34 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 34C02

Produktdetails anti-CD34 Antikörper

Spezifität: This antibody reacts with CD34 - expressed on lymphoid and myeloid hematopoietic progenitor cells. Also reacts with vascular endothelial cells in normal tissues and in benign and malignant proliferations.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Protein G Chromatography

Immunogen: Recombinant Human CD34 protein.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry. Immunohistology on Frozen Material.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in sterile Water to a concentration of 1.0 mg/mL.

Buffer: 10 mM PBS, pH 7.4 without preservatives or stabilizers

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: The lyophilized antibody, though stable at RT, is best stored desiccated below 0 °C. Reconstituted antibody is stable at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CD34

Target: CD34

Andere Bezeichnung: CD34

Hintergrund: The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence. CD34, a single chain transmembrane glycoprotein, is selectively expressed on human lymphoid and myeloid hematopoietic progenitor cells.Synonyms: Hematopoietic progenitor cell antigen CD34, Hematopoietic progenitor cell marker

Gen-ID: 947

NCBI Accession: NP_001020280

UniProt: P28906